Publicaciones

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1. Escribano L, Orfao, A., Villarrubia, J., Cerveró, C., Velasco, J.L., Martín, F., San Miguel, J.F., and Navarro, J.L. Expression of lymphoid-associated antigens in blood and bone marrow mast cells in a case of systemic mast cell disease. Br.J.Haematol. 91:941-943, 1995. PMID: 8547146
http://www.ncbi.nlm.nih.gov/pubmed?term=8547146


2. Orfao A, Escribano L, Villarrubia J, Velasco JL, Cerveró C, Ciudad J, Navarro JL, San Miguel JF. Flow cytometric analysis of mast cells from normal and pathological human bone marrow samples. Identification and enumeration. Am J Pathol 149:1493-1499, 1996. PMID: 8909239
http://www.ncbi.nlm.nih.gov/pubmed?term=8909239


3. Escribano L, Orfao A, Villarrubia J, Martín F, Madruga JI, Cuevas M, Velasco JL, Rios A, San Miguel JF. Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia.  Cytometry. 1997; 30:98-102. PMID: 9149916
http://www.ncbi.nlm.nih.gov/pubmed?term=9149916


4. Escribano L, Orfao A, Díaz Agustín B, Villarrubia J, Cerveró C, López A, García Marcos A, Bellas C, Fernández Cañadas S, Cuevas M, Sanchez A, Velasco JL, Navarro JL, San Miguel JF. Indolent systemic mast cell disease in adults. immunophenotypic characterization and its diagnostic implications.  Blood. 1998; 91:2731-2736. PMID: 9531582
http://www.ncbi.nlm.nih.gov/pubmed?term=9531582


5. Escribano L, Ocqueteau M, Almeida J, Orfao A, San Miguel JF. Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis.  Leuk.Lymphoma. 30:459-466, 1998. PMID: 9711908
http://www.ncbi.nlm.nih.gov/pubmed?term=9711908


6. Escribano,L.; Orfao,A.; Villarrubia,J.; Díaz Agustín,B.; Cerveró,C.; Ríos,A.; Velasco,J.L.; Ciudad,J.; Navarro,J.L.; San Miguel,J.F.Immunophenotypic characterization of human bone marrow mast cells. A flow cytometric study of normal and pathological bone marrow samples. An.Cell.Pathol 16:151-159, 1998. PMID: 9699944
http://www.ncbi.nlm.nih.gov/pubmed?term=9699944


7. Escribano, L; Alberto Orfao, Beatriz Díaz Agustín, Carlos Cerveró, Sonia Herrero, Jesús Villarrubia, Pilar Bravo, Antonio Torrelo, Teresa Montero, Mercedes Valdemoro, José Luis Velasco, José Luis Navarro, Jesús F. San Miguel. Human bone marrow mast cells from indolent systemic mast cell disease constitutively express increased amounts of the CD63 protein on their surface. Cytometry 34:223-228, 1998. PMID: 9822308
http://www.ncbi.nlm.nih.gov/pubmed?term=9822308


8. Carlos Cerveró, Escribano,L; Alberto Orfao, Beatriz Díaz-Agustín, Pilar Bravo, Jesús Villarrubia, Ramón García-Sanz, José L. Velasco, Pilar Herrera, Mario Vargas, Marcos González, José L. Navarro, Jesús F. San Miguel. expression of bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia. Am J Hematol 60:191-195, 1999. PMID: 10072109
http://www.ncbi.nlm.nih.gov/pubmed?term=10072109


9. B. Díaz Agustín, Escribano,L; P. Bravo, S. Herrero, R. Nuñez, R. Navalón, A. Torrelo, A. Cantalapiedra, L. Del Castillo, J. Villarrubia, J. L. Navarro, J. F. San Miguel, and A. Orfao. The CD69 early activation molecule is overexpressed in human bone marrow mast cells from adults with indolent systemic mast cell disease. Br.J.Haematol. 106:400-405, 1999. PMID: 1046059
http://www.ncbi.nlm.nih.gov/pubmed?term=10460598


10. Escribano,L;  Beatriz Díaz-Agustín, Carmen Bellas, Raquel Navalón, Rosa Nuñez, Wolfgang R. Sperr, Gerit-Holger Schernthaner, Peter Valent, Alberto Orfao. Utility of Flow Cytometric Analysis of mast cells in the diagnosis and classification of adult mastocytosis. Leuk Res 25:563-570, 2001. PMID: 11377681
http://www.ncbi.nlm.nih.gov/pubmed?term=11377681


11. P Valent, H-P. Horny, Escribano,L, B. J Longley, C Y. Li, L B. Schwartz, G Marone, R Nuñez, C Akin, K Sotlar, W R. Sperr, K Wolff, R D. Brunning, R M. Parwaresch, FK. Austen, K Lennert, D D. Metcalfe, JW. Vardiman, J M. Bennett. Diagnostic Criteria and Classification of  Mastocytosis: A Consensus Proposal. Conference-Report: ´Year 2000 Working Conference on Mastocytosis´. Leuk Res 25:529-536, 2001. PMID: 11377686
http://www.ncbi.nlm.nih.gov/pubmed?term=11377686


12. WR. Sperr,Escribano,L ;J-H Jordan, G-H Schernthaner, M Kundi, H-P Horny, P Valent.Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 25:603-25, 2001. PMID: 11377677
http://www.ncbi.nlm.nih.gov/pubmed?term=11377677


13. P. Valent, G.-H. Schernthaner, H. Agis, G. Fritsch, M. Willheim, H.-J. Bühring, A. Orfao Escribano.L;  Variable expression of activation-linked surface antigens on human mast cells in health and disease. Immunological Reviews 179:74-81, 2001. PMID: 11292030
http://www.ncbi.nlm.nih.gov/pubmed?term=11292030


14. G. Schernthaner, J. H. Jordan, M. Ghannadan, H. Agis, D. Bevec, R. Núñez, Escribano,L ; O. Majdic, M Willheim, C Worda, D. Printz, G. Fritsch, K. Lechner, and P. Valent. Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Blood  98:3784-3792, 2001. PMID: 11739187
http://www.ncbi.nlm.nih.gov/pubmed?term=11739187


15. Escribano L, Diaz-Agustin B, Nunez R, Prados A, Rodriguez R, Orfao A. Abnormal Expression of CD Antigens in Mastocytosis. Int Arch Allergy Immunol 2002 Feb;127(2):127-32. PMID: 11919422
http://www.ncbi.nlm.nih.gov/pubmed?term=11919422


16. Escribano L, Akin C, Castells M, Orfao A, Metcalfe D. Mastocytosis: Current concepts in diagnosis and treatment. Ann Hematol, 2002,  81:677-690. PMID: 12483363
http://www.ncbi.nlm.nih.gov/pubmed?term=12483363


17. Escribano L, Pérez de Oteyza J, Núñez R, Orfao A. Cladribine induces Immunophenotypical changes in Bone Marrow Mast Cells from Mastocytosis. Report of a Case of Mastocytosis associated with a Lymphoplasmacytic Lymphoma. Leuk Res, 26:1043-1046, 2002. PMID: 12363474
http://www.ncbi.nlm.nih.gov/pubmed?term=12363474


18. Sperr, W.R., Jordan, J.H., Fiegl, M., Escribano, L, Bellas, C., Dirnhofer, S., Semper, H., Simonitsch-Klupp, I., Horny, H.P., Valent, P. (2002) Serum tryptase levels in patients with mastocytosis: Correlation with mast cell burden and implication for defining the category of disease. Int. Arch. Allergy Immunol. 128, 136-141. PMID: 12065914
http://www.ncbi.nlm.nih.gov/pubmed?term=12065914


19. K. Sotlar, Escribano,L; Olzert. Landt, S Möhrle, S. Herrero, A. Torrelo, Ulrich Lass, H.-P. Horny, and Burkhard Bültmann. One-Step Detection of c-kit Point Mutations Using PNA-Mediated PCR-Clamping and Hybridization Probes. Am.J.Pathol 162(3):737-46, 2003. PMID: 12598308
http://www.ncbi.nlm.nih.gov/pubmed?term=12598308


20. Peter Valent , Cem Akin, Wolfgang R. Sperr, Escribano,L; Michel Arock, Hans-Peter Horny, John M. Bennett, Dean D. Metcalfe. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leukemia Research 27 (2003) 635–641. PMID: 12681363
http://www.ncbi.nlm.nih.gov/pubmed?term=12681363


21. R. Nuñez, Escribano,L ; G. Schernthaner, A Prados, R. Rodriguez-Gonzalez, B. Diaz-Agustin, A. Lopez, A. Hauswirth, P. Valent, J. Almeida, P. Bravo, and A Orfao. Overexpression of complement receptors and related antigens on the surface of bone marrow mast cells in patients with systemic mastocytosis. Br. J. Haematol. 120(2):257-65, 2003. PMID: 12542483
http://www.ncbi.nlm.nih.gov/pubmed?term=12542483


22. Escribano,L;  B. Diaz-Agustin, A. Lopez, R. Nunez, A. C. Garcia-Montero, J. Almeida, A Prados, M Angulo, and A Orfao. Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it?. Proposals of the Spanish Network on Mastocytosis (REMA). Cytometry Part B (Clinical Cytometry) 58B:1-8, 2004. PMID: 14994369
http://www.ncbi.nlm.nih.gov/pubmed?term=14994369


23. Escribano.L, A García-Montero, R Núñez-López, J López-Jiménez, J Almeida, A Prados, A Orfao. Systemic mastocytosis associated with acute myeloid leukemia: Case report and implications for disease pathogenesis. Journal Of Allergy and Clinical Immunology, 2004; 114: 28-33. PMID: 15241340
http://www.ncbi.nlm.nih.gov/pubmed?term=15241340


24. Luis Escribano, Cem Akin, Mariana Castells and Lawrence B. Schwartz. Current Options in the Treatment of Mast Cell Mediator-Related Symptoms in Mastocytosis. Inflammation & Allergy - Drug Targets, 2006;5:61-77 PMID: 16613565
http://www.ncbi.nlm.nih.gov/pubmed?term=16613565


25. Garcia-Montero A, Jara-Acevedo M, Teodosio C, Sanchez ML, Nunez R, Prados A, Aldanondo I, Sanchez L, Dominguez M, Botana LM, Sanchez-Jimenez F, Sotlar K, Escribano L,  Orfao A.. c-kit mutation in mast cells and other bone marrow haematopoietic cell lineages in systemic mast cell disorders. A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood. 2006 Oct 1;108(7):2366-72 PMID: 16741248
http://www.ncbi.nlm.nih.gov/pubmed?term=16741248


26. Escribano, L. et al. "Flow cytometric analysis of normal and neoplastic mast cells: role in diagnosis and follow-up of mast cell disease." Immunol.Allergy Clin.North Am. 26.3 (2006): 535-47. PMID:16931292
http://www.ncbi.nlm.nih.gov/pubmed?term=16931292


27. Valent P, Akin C, Escribano L, Födinger M, Hartmann K, Brockow K, Castells M, Sperr WR, Kluin-Nelemans HC, Hamdy NA, Lortholary O, Robyn J, van Doormaal J, Sotlar K, Hauswirth AW, Arock M, Hermine O, Hellmann A, Triggiani M, Niedoszytko M, Schwartz LB, Orfao A, Horny HP, Metcalfe DD. Standards and standardization in mastocytosis: Consensus Statements on Diagnostics, Treatment Recommendations and Response Criteria Eur J Clin Invest 2007;37:435-53 PMID: 17537151
http://www.ncbi.nlm.nih.gov/pubmed?term=17537151


28. Orfao A, Garcia-Montero AC, Sanchez L, Escribano L. Recent advances in the understanding of mastocytosis: the role of KIT mutations. Br J Haematol. 2007 Jul;138(1):12-30. PMID:17555444
http://www.ncbi.nlm.nih.gov/pubmed?term=17555444


29. Löber K, Alfonso A, Escribano L, Botana LM.STI571 (Glivec(R)) affects histamine release and intracellular pH after alkalinisation in HMC-1(560, 816).  Eur J Clin Invest  15;103(3):865-76.PMID:17615556
http://www.ncbi.nlm.nih.gov/pubmed?term=17615556


30. D. González de Olano, B. de la Hoz Caballer, R. Núñez López, L. Sánchez Muñoz, M. Cuevas Agustín, MC Diéguez,  I. Álvarez Twose, MC Castells, L. Escribano Mora. Prevalence of Allergy and Anaphylactic Symptoms in 210 Adult and Pediatric Patients with Mastocytosis in Spain. A study of the Spanish Network on Mastocytosis (REMA). Clin Exp Allergy, 2007 Oct;37(10):1547-55. PMID:17883734
http://www.ncbi.nlm.nih.gov/pubmed?term=17883734


31. Löber K, Alfonso A, Escribano L, Botana LM Influence of the tyrosine kinase inhibitors STI571 (Glivec(R)), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem. 2008. 103(4):1076-88 PMID: 17661356
http://www.ncbi.nlm.nih.gov/pubmed?term=17661356


32. D. González de Olano  I. Álvarez Twose, M.I. Esteban López, L. Sánchez Muñoz,  M.D. Alonso Díaz de Durana, A. Vega Castro, A. García Montero, E. González Mancebo, T. Bellver González, M.D. Herrero Gil, M. Fernández-Rivas, A. Orfao, B. de la Hoz Caballer, MC Castells, L. Escribano. Safety and Effectiveness of Immunotherapy in Indolent Systemic Mastocytosis Patients Presenting with Hymenoptera Venom Anaphylaxis. J Allergy Clin Immunol. 2008 Feb;121(2):519-26 PMID: 18177694. 2008 Jan 2; (Epub)
http://www.ncbi.nlm.nih.gov/pubmed?term=18177694


33. Hauswirth AW, Escribano L, Prados A, Nunez R, Mirkina I, Kneidinger M, Florian S, Sonneck K, Vales A, Schernthaner GH, Sanchez-Muñoz L, Sperr WR, Buhring HJ, Orfao A, Valent P. CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking. Int J Immunopathol Pharmacol 2008 21(4):797-806. PMID: 19144265
http://www.ncbi.nlm.nih.gov/pubmed?term=19144265


34. L Escribano, I Álvarez-Twose, L Sánchez-Muñoz, A Garcia-Montero, R Núñez, J Almeida, M Jara-Acevedo, C Teodósio, M García-Cosío, C Bellas, A Orfao. Prognosis in Adult Indolent Systemic Mastocytosis: a Long-Term Study of the Spanish Network on Mastocytosis in a Series of 145 Patients. J Allergy Clin Immunol. J Allergy Clin Immunol. 124(3):514-21. Epub 2009 Jun 19. PMID: 19541349
http://www.ncbi.nlm.nih.gov/pubmed?term=19541349


35. Álvarez-Twose, D González de Olano, L Sánchez-Muñoz, A Matito, MI. Esteban-López, A Vega, MB Mateo, MD. Alonso Díaz de Durana, B de la Hoz, MD. del Pozo Gil, T Caballero, A Rosado, I Sánchez Matas, C Teodósio, M Jara-Acevedo, M Mollejo, A García-Montero, A Orfao, and L Escribano. Clinical, biological and molecular characteristics of clonal mast cell disorders presenting with mast cell activation symptoms.  J Allergy Clin Immunol. 2010 Jun;125(6):1269-1278.e2. PMID: 20434205
http://www.ncbi.nlm.nih.gov/pubmed?term=20434205


36. Teodosio C, García-Montero AC, Jara-Acevedo M, Sánchez-Muñoz L, Alvarez-Twose I, Núñez R, Schwartz LB, Walls AF, Escribano L, Orfao A. Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes. J Allergy Clin Immunol. 2010 Mar;125(3):719-26, 726.e1-726.e4. Epub 2010 Jan 12 PMID: 20061010
http://www.ncbi.nlm.nih.gov/pubmed?term=20061010


37. Matito A, Álvarez-Twose I, Sánchez-Muñoz L, Morgado JM, Orfao A, Escribano L. Clinical impact of pregnancy in mastocytosis: a study of the Spanish Network on Mastocytosis (REMA) in 45 cases. Int Arch Allergy Immunol. 2011;156(1):104-11 PMID:21447966

http://www.ncbi.nlm.nih.gov/pubmed?term=21447966

 
38. Vano-Galvan S, Alvarez-Twose I, De Las Heras E, Morgado JM, Matito A, Sánchez-Muñoz L, Planas MN, Jaén P, Orfao A, Escribano L, Dermoscopic features of skin lesions in 127 patients with mastocytosis. Archives of Dermatology. 2011 Aug;147(8):932-40 PMID:21844452

http://www.ncbi.nlm.nih.gov/pubmed?term=21844452


39. D. González-de-Olano, I. Álvarez-Twose, J.M. Morgado, M.I. Esteban López, A. Vega Castro, M.D. Alonso Díaz de Durana, L. Sánchez-Muñoz, A. Matito, B. de la Hoz Caballer, M.L. Sanz, A. Orfao, L. Escribano. Evaluation of Basophil Activation in Mastocytosis with Hymenoptera Venom Anaphylaxis. Cytometry Part B, Clinical Cytometry. 2011 May;80(3):167-75 PMID: 21520404

http://www.ncbi.nlm.nih.gov/pubmed/21520404